The Chicago White Sox were eliminated from the playoffs after a 2-0 loss to the Cleveland Guardians in a decisive Game 5. Cleveland advanced to the American League Championship Series.

José Ramírez supplied both runs with a fourth-inning homer off Sean Burke. Burke pitched five innings, allowing two runs and striking out four.

Guardians pitcher Gavin Williams held Chicago to one hit and struck out 12 in his third appearance of the series. The White Sox struck out 21 times, breaking the nine-inning playoff record of 19 they had set days earlier.

Chicago's best chance came in the sixth. Colson Montgomery was hit by a pitch, Kyle Teel singled and Miguel Vargas walked to load the bases with two outs, ending Williams' outing. The White Sox did not score.